Are the various GHRP a scam, or do they actually work?

[AlexDavis43]

Stop fixating on drugs and eat more.

There isn't a drug on the planet that will benefit your situation more than a reasonable calorie surplus.

yes and tren right?

 

[AssociateX]

Not all peptides are GHRHs or GHRPs. Some are for healing, tanning skin, sleep aids, sexual stimulants, neurological and that's all I have off the top of my head. I have more info in my notes somewhere.

Concerning GHRHs and GHRPs, in a nutshell:
GHRPs (GHRP-6, GHRP-2, Hexarelin, Ipamorelin) are like cardiac shock paddles. You administer a GHRP and a pulse of GH is created. This is predictable and reliable across all normal people.

GHRH creates no pulse. It only adds to what ever is happening naturally. If there is a pulse occurring then GHRH increases the GH release. If no pulse is occurring when GHRH is administered then it will have little effect on GH release.

Below is from my notes, but someone else wrote it.


The Body's Growth Hormone System & Peptides
Besides Growth hormone (GH) itself, your body utilizes three basic hormones:

Growth Hormone Releasing Hormone (GHRH)- Released by the brain to tell your bodies growth hormone storage cells (somatotrophs) to release growth hormone.

Somatostatin- Acts as the "off switch" and tells your cells (somatotrophs) to cease growth hormone release.

Ghrelin- Created in the stomach, this hunger derived hormone reduces Somatostatins "off switch" effect and encourages the brain to release more GHRH.

If GHRH is always around the somatotrophs (GH storing cells) are constantly releasing and unable to store GH. This results in a constant dribble or "bleed" of GH rather than a big pulse. Growing, development, and maturity requires GH to be released in a pulsatile manner.

This is where Somatostatin comes into play. It instructs your somatotrophs to cease the GH release allowing them to begin storing and stockpiling GH. However if Somatostatin is always present the body would never release enough GH to function. What if GHRH and Somatostatin are trying to work at the same time? For the most part Somatostatin is stronger and no GH will be released.

Further benefiting this hormonal seesaw is Ghrelin. When Ghrelin makes its way up to the brain it makes it easier for GHRH to do it's job by suppressing Somatostatins effects. It is possible for Ghrelin on its own to cause a GH release even with a high Somatostatin presence. However, GHRH and Ghrelin together have a synergistic GH effect, meaning that the spike of GH released is larger than could have been produced by each on their own.

Synthetic forms of Ghrelin exist known as Growth Hormone Releasing Peptides (GHRP's) and act in the same way that natural Ghrelin does.

Growth Hormone Releasing Hormones (GHRH):
CJC-1295

CJC-1293

GRF(1-29)

Sermorelin

Modified GRF(1-29)

Which GHRH?
GRF(1-29) and Sermorelin are essentially the same thing. Sermorelin just being the name of a FDA-approved version of GRF(1-29). The issue here is that these are easily rendered ineffective within minutes of injecting due to destruction by blood enzymes (unless you could pin directly into your pituitary gland). What remains of the list are analogs, or altered versions, of the original GRF(1-29).

Using an anolog that is able to survive blood enzymes for around 30 minutes is ideal

CJC-1293 is GRF(1-29) with 1 amino acid swap plus the Drug Affinity Complex (DAC). DAC acts as a velcro holding the amino acids together for a longer period of time. The single amino acid swap makes the analog peptide stronger but not by enough. The half-life is maybe double GRF(1-29) in humans. So 5 minutes of half-life.

CJC-1295 is GRF(1-29) with 4 amino acid alterations and the Drug Affinity Complex (DAC). This version is extra strong and will last more than 30 minutes and the DAC increases the half-life even more by preventing breakdown by blood enzymes.

Here is the interesting part: You do not want to use any of the CJC's. The first (CJC-1293) does not survive long enough after injection and the second (CJC-1295) survives for too long and is always around preventing Somatostatin from stopping GH release resulting in a GH bleed.

What do you want to use? You want an analog that utilizes those 4 amino acid swaps and mantains the ability to still be broken down after those 30 or so minutes. This is known as Modfied GRF(1-29).

**There is debate as to whether or not CJC-1295 without DAC is the same as Mod GRF(1-29)

Growth Hormone Releasing Peptides, Ghrelin-mimetics (GHRP):
GHRP-6

GHRP-2

Ipamorelin

Hexarelin

Which GHRP?
Hexarelin is the strongest in the family known to give the biggest pulse of all. Will create prolactin and cortisol side effects. Desensitization will happen regardless of the dose.

GHRP-2 has the second strongest GH release, lower hunger effect, and no gastric motility. GHRP-2 will result in the most bang for your buck. This is a second generation GHRP. Usage of this peptide can also come with elevated levels of cortisol and prolactin. Desensitization is unclear if used beyond saturation dose.

GHRP-6 has the second strongest GH release. It can cause an intense hunger effect and gastric motility. This is a first generation GHRP. Slightly creates prolactin and cortisol issues. Desensitization does not occur.

Ipamorelin does not release as much GH as other GHRPs, but at very large doses was shown to give a large release of GH without desensitization. Has no almost no hunger effect. This mildest in the bunch, but does not create prolactin or cortisol.

Dosing Schedules
Injecting a GHRH on its own is not very effective since you are unable to know when your bodies somatostatin is active. Because of this you'll need to pick a GHRP to be paired with your GHRH of choice. This ensures that Somatostatin, if present, will be suppressed and the two peptides will synergistically amplify the natural GH pulse.

Dosing is going to be mostly dependent on your goals and it is generally recommended to asses your tolerance before diving right into multiple doses per day. Starting slow and gradually increasing to multiple doses per day may alleviate some side effects

Note: a saturation dose is defined as 1mcg/kg of bodyweight or 100mcg, the latter being the most commonly used (except in Hexarelin in which 200mcg is considered the saturation dose). Some minority of people have sleep interruption rather than better sleep from pre-bed dosing. Often a move from GHRP-6, GHRP-2, or Hexarelin to the smoother Ipamorelin will remedy this. If not moving the pre-bed dose to the morning often does.

Minimalist- Dosing below saturation levels pre-bed i.e.: ~50mcg each of a GHRP and GHRH

Pre-bed Saturation- 100mcg of each GHRP (except Hexarelin) and GHRH. Results in better overall health, recovery and well being. This is a solid general anti- aging protocol.

Pre-bed & Post Workout Saturation Dose- PWO serves protein metabolism well and increases protein synthesis. Twice a day saturation doses has increased recovery, contribution to anabolism, injury healing, better well being and serious anti-aging properties.

Pre-bed, PWO, and Morning Saturation Doses- The morning dose, when fasted, engages the release of fatty acids which can be burned off for energy during activity. Three saturation doses per day further increases anabolism and decreases catabolism. Local growth factors will rise including systemic IGF-1, but within physiological levels, resulting in no enhanced health dangers, no abnormal organ or structural growth.

There are more advanced dosing protocols but for simplicity they have been left out of this text.

Administration
For best results doses should be administered on an empty stomach (2 or so hours after eating) or with only protein in the stomach. Fats and Carbs blunt the bodies GH release. So, administer your dose, wait 20 minutes for the GH pulse to reach its peak and then you can eat Carbs or fats without having to worry about blunting the GH pulse. If dosing multiple times per day allow at least 3 hours between administrations.

 

[AssociateX]

Here is an example of some peptides, their function(s), and suggested dosing. I cropped it out of a PDF from an online 'pharmacy' (looks more like an online clinic).

 

[AssociateX]

At this point in my peptide journey, I don't give two shits about the GHRPs and GHRHs for natural HGH release in the body. I think it's cheaper, easier, faster, and just more beneficial to use HGH.

With that said, there are some peptides that are pretty bitchin'.

Melanotan2 is great for tanning, while also increasing libido.

PT-141 is a MT2 derivative that just focuses on the libido part, which works for both men and women.

BPC-157/TB500 is great for joint pains from injured ligaments and tendons. HGH may also do this, someone else would have to say so though.

DSIP is a non-sedative sleep aid. I've taken it and as long as I turn off my phone and lights, put my head on my pillow, I fall asleep right away (which is not normal for me, I toss and turn a lot). DSIP does not make you groggy the next day. I've heard that HGH makes for a good nights rest too though.

N-Acetyl Semax Amidate has an odd effect on mental clarity and sharpness that isn't great but it is noticeable. YMMV.

For DNP users, look up how to use SS-31 followed by MOTS-c to help optimize your mitochondria for the upcoming DNP triphosphate uncoupling. (I'm building a whole regiment that includes other compounds for mitochondrial optimization as well. I am just not done putting it together yet.)

IGF-1 LR3 is kind of neato for the pump that it helps with, but I read a lot about how the gains are just superficial and don't last. I've tried it, got a good pump, but won't be buying it again.

All of the GLP-1 (Glucagon-like peptide-1) agonists, tirzepatide, semaglutide, retatrutide, and so on, really help with discipline to a diet plan. I used tirzepatide with tesofensine and was able to not cheat at all on my meal plan. There are a bunch of fatties out there that think GLP-1s are a magic carpet to keep going to the buffet, but that is not the case and they struggle with their weight and dose titrations. My guess is that the doctors (sanctioned dope dealers) gave the drugs with little impression for proper nutritional knowledge to be disciplined to, but I'm just guessing there.

Then there are some beneficial peptides that are just too freakin' expensive, like NAD+, which also helps with mitochondrial health and optimization. The thing is, you can buy capsules/tablets of NAD+ and precursors with great bio-availability for about 5-10 times cheaper.

That's all off of the top of my head without looking through my notes. There are other non-GHRH and GHRP peptides that are good outside of the use of HGH, you'll just have to look them up for your use case(s).

With that said, I've picked up some HGH and am giving up on encouraging natural production of GH through peptides. HGH is just less expensive and with better/faster benefits.

If anyone is interested in a ton of notes, PDFs, eBooks, and so on, let me know and I'll zip up and send you what I have.

 

[AssociateX]

I zipped all of the peptide docs that I have and the zip file ended up being 170 mb. If you want it, let me know how to get it to you or others.

I will also add, for the curious, that I never went up with the tirzepatide. I stayed at the minimum dose of 2.5 mg, but I did change the frequency from 7 days to 5 days for less peaks and lows and slightly higher blood levels. A person can plug in numbers at https://glp1plotter.com/ and see a chart of different doses and levels and frequencies. There is interesting info at the bottom of the page, too. Personally, it was totally not needed to go up in dosage like I saw so many of the fatties on Reddit do. I also used the stuff for less than two months. The tesofensine I used at 500 mcg a day first thing in the morning after waking up.

I was reading through the docs last night and one book said that they preferred 1mL syringes. I found that 0.5mL syringes were way easier to read. I reconstituted everything that I made into 5iu doses, if it was 250mcg or 500mcg they ended up 5 iu. Out of all of the peptides I used all of them could be mixed with other peptides, so one syringe was enough for multiple peptides at once. I used 29 gauge needles, which slip right in with little to no pain.

One thing about the docs, they have different takes on dose, frequency, and cycle length when applicable. For the dose, I found that finding out what the saturation dose of any peptide to be very helpful. Then, what dose was good for maintenance, which was not always the same as the saturation dose. Some peptides had cycle lengths, so you could take year round, so know what you're taking and how to use it. Melanotan2 is a good example where I saw some dumbshit suggest to another person to take 1 mg daily until dark. The dose, if I remember right, is 250 mcg until tan, but it sneaks up on you. You have to watch to make sure your moles don't get too dark. After you're tan like you want, its 250 once a week. Also, 1 mg a day would give you 24/7 raging boner, NO JOKE, while also becoming oddly/unnaturally tan. Make sure you know what your'e doing.

So, back to tirz: The tirzepatide came in a variety of sizes, but I got the 15 mg vials and reconstituted with 0.9mL of bacteriostatic water so my draws would be 15 iu and easier to draw than 16.7 iu if I used 1mL or bac water. Use what ever calculator you want, but I really like https://peptidecalc.com/. Tirzepatide is the only one that I did NOT reconstitute to 5 iu doses.