Starting to hear about more guys doing it IM. I’d definitely prefer subQ because my injection sites for IM take a beating as it isI've never really known anyone to do it IM, I've always been under the assumption SubQ was the standard administration method.
Sub Q for GH always .Is one method any better than the other when it comes to GH?
Exactly . This is fact . I've seen the literature that supports this as well . I thought it was well known this is why SubQ is the standard for hGH and Ii believe GF-1 use as well.Sub Q is the standard for a reason:
However, the absorbance profile and bioavailability of SC- and IM-injected hGH has shown inconsistencies. For example, hGH (1.3 mg/m2/day) reaches its peak plasma concentration (Tmax) at 2 and 4 hours and returns to its baseline after 9 and 18 hours following IM and SC injections, respectively. Accordingly, the available time for absorption of hGH following IM injection is not long enough to provide physiologically-relevant plasma levels by daily administration. The longer retention time of the biopharmaceuticals at the SC injection site provides extended drug release compared to IM injection. Rapid drug absorption upon IM injection is due to the high vasculature of the muscle tissue.
My eyes hurt, but good post.Sub Q is the standard for a reason:
However, the absorbance profile and bioavailability of SC- and IM-injected hGH has shown inconsistencies. For example, hGH (1.3 mg/m2/day) reaches its peak plasma concentration (Tmax) at 2 and 4 hours and returns to its baseline after 9 and 18 hours following IM and SC injections, respectively. Accordingly, the available time for absorption of hGH following IM injection is not long enough to provide physiologically-relevant plasma levels by daily administration. The longer retention time of the biopharmaceuticals at the SC injection site provides extended drug release compared to IM injection. Rapid drug absorption upon IM injection is due to the high vasculature of the muscle tissue.