GH intramuscular or subQ?

Jonjon

Senior Member
Joined
Jun 21, 2021
Messages
1,405
Reaction score
1,425
Points
113
Is one method any better than the other when it comes to GH?
 
Joined
May 12, 2024
Messages
470
Reaction score
813
Points
63
I've never really known anyone to do it IM, I've always been under the assumption SubQ was the standard administration method.
 

Jonjon

Senior Member
Joined
Jun 21, 2021
Messages
1,405
Reaction score
1,425
Points
113
I've never really known anyone to do it IM, I've always been under the assumption SubQ was the standard administration method.
Starting to hear about more guys doing it IM. I’d definitely prefer subQ because my injection sites for IM take a beating as it is
 
Joined
Jun 23, 2023
Messages
39
Reaction score
25
Points
3
Sub Q is the standard for a reason:

However, the absorbance profile and bioavailability of SC- and IM-injected hGH has shown inconsistencies. For example, hGH (1.3 mg/m2/day) reaches its peak plasma concentration (Tmax) at 2 and 4 hours and returns to its baseline after 9 and 18 hours following IM and SC injections, respectively. Accordingly, the available time for absorption of hGH following IM injection is not long enough to provide physiologically-relevant plasma levels by daily administration. The longer retention time of the biopharmaceuticals at the SC injection site provides extended drug release compared to IM injection. Rapid drug absorption upon IM injection is due to the high vasculature of the muscle tissue.
 
Joined
Nov 22, 2024
Messages
14
Reaction score
4
Points
3
Sub Q is the standard for a reason:

However, the absorbance profile and bioavailability of SC- and IM-injected hGH has shown inconsistencies. For example, hGH (1.3 mg/m2/day) reaches its peak plasma concentration (Tmax) at 2 and 4 hours and returns to its baseline after 9 and 18 hours following IM and SC injections, respectively. Accordingly, the available time for absorption of hGH following IM injection is not long enough to provide physiologically-relevant plasma levels by daily administration. The longer retention time of the biopharmaceuticals at the SC injection site provides extended drug release compared to IM injection. Rapid drug absorption upon IM injection is due to the high vasculature of the muscle tissue.
Exactly . This is fact . I've seen the literature that supports this as well . I thought it was well known this is why SubQ is the standard for hGH and Ii believe GF-1 use as well.
 

Jonjon

Senior Member
Joined
Jun 21, 2021
Messages
1,405
Reaction score
1,425
Points
113
Well a month on intramuscular with phenomenal results. I’ll try subQ for a bit and get bloodwork and we’ll know which is better
 

SFGiants

Elite
Joined
Apr 29, 2012
Messages
11,370
Reaction score
16,168
Points
383
Sub Q is the standard for a reason:

However, the absorbance profile and bioavailability of SC- and IM-injected hGH has shown inconsistencies. For example, hGH (1.3 mg/m2/day) reaches its peak plasma concentration (Tmax) at 2 and 4 hours and returns to its baseline after 9 and 18 hours following IM and SC injections, respectively. Accordingly, the available time for absorption of hGH following IM injection is not long enough to provide physiologically-relevant plasma levels by daily administration. The longer retention time of the biopharmaceuticals at the SC injection site provides extended drug release compared to IM injection. Rapid drug absorption upon IM injection is due to the high vasculature of the muscle tissue.
My eyes hurt, but good post.
 
Top