Low SHGB

[Texan69]

Got labs back my SHGB was 7.5 which is low, the range is 10-50.

From my understanding low SHGB means more of your test can be used. Downsides could be acne, balding and higher levels of testosterone

Total test came back at 2000 and free test ce back at 800

Estrogen 56

300mg test and 400mg of Masteron weekly
HCG as well.

 

[CJ]

From my understanding low SHGB means more of your test can be used.

Not really. SHBG and Albumin are what transport testosterone (and estrogen) throughout the body. When Testosterone is bound to SHBG, it can't be used, but even though it has a high binding affinity, it's not permanent. It will release that Testosterone.

Albumin on the other hand, has a weaker binding affinity.

 

[Texan69]

Not really. SHBG and Albumin are what transport testosterone (and estrogen) throughout the body. When Testosterone is bound to SHBG, it can't be used, but even though it has a high binding affinity, it's not permanent. It will release that Testosterone.

Albumin on the other hand, has a weaker binding affinity.

Is the low SHBG something I need to address ?

 

[TODAY]

Is the low SHBG something I need to address ?

How's your blood pressure?

Mood?

Are you experiencing skin problems?

How about your kidney and liver numbers?

 

[CJ]

Is the low SHBG something I need to address ?

I don't know.

 

[eazy]

of course he wouldn't worry he's not the guy with the 7, whose stuff is not getting where it needs to go

 

[Jeffgoldblumlipswork]

Wasn't everyone trying to lower their SHBG two years ago?

 

[Jonjon]

No reason to even check shbg in my opinion
You can’t do anything about it anyway. Everyone who takes gear will be single digit shbg eventually.

 

[eazy]

someone said site sources, I don't think he did. LINK

main takeaway

When steroids are used, SHBG becomes nearly irrelevant because androgen levels grossly outweigh the binding capacity of SHBG. In a normal, healthy male, there are more SHBG glycoproteins than there are molecules of androgen. In a steroid user, SHBG becomes oversaturated and the liver attempts to address the androgen excess by reducing SHBG concentration to speed up the clearance (removal) of androgens from the body. However, due to the relentless exogenous supply of androgen, the liver's effort is futile. MCR is maximized and overridden.

full comment

There is no such thing as waste with SHBG. The broscience is that SHBG "stealz ur T", but the exact opposite is true. SHBG does not metabolize or destroy testosterone. SHBG does not "steal" T and then perform some biochemical magic to make the T vanish from the universe, either.

SHBG prevents the metabolism of testosterone and slows down your overall MCR (metabolic clearance rate) by preventing the liver from destroying testosterone and also prolonging the action of T within cells (SHBG passes into the cell via endocytosis instead of free diffusion.)

SHBG+T has an approximate half-life of 2 hours in serum. Then, the complex dissociates. The T is returned to the bloodstream — intact.

Do you know what wastes your testosterone/other compound? The liver. Get rid of the liver and you'll enjoy all the benefits of your pinning. Also, stop cellular glucuronidation and you're "GTG", as they say.

Decreasing SHBG is the fastest and most guaranteed way ensure free androgens are removed from your body as rapidly as possible.

In healthy men with naturally high testosterone levels, SHBG correlates positively with TT.

When steroids are used, SHBG becomes nearly irrelevant because androgen levels grossly outweigh the binding capacity of SHBG. In a normal, healthy male, there are more SHBG glycoproteins than there are molecules of androgen. In a steroid user, SHBG becomes oversaturated and the liver attempts to address the androgen excess by reducing SHBG concentration to speed up the clearance (removal) of androgens from the body. However, due to the relentless exogenous supply of androgen, the liver's effort is futile. MCR is maximized and overridden.

Excessive SHBG can interfere with passive diffusion through cellular membranes by limiting the concentration of T in its free moiety. Aromatization slows and both DHT and E2 become excessively bound to SHBG, limiting the immediate action of all major steroid hormones before they are degraded.

Normal SHBG slows MCR, prevents over-metabolization and also enhances cellular uptake and retention by reducing the glucuronidation and efflux of FT from cells and excites the SHBG-R receptor to increase cellular cAMP. SHBG at adequate level preserves testosterone and enhances the action of two pathways: the endocytic pathway and the extracellular (SHBG-R) pathway. (Androgens bind to SHBG which has already bound to extracellular megalin.)

Insufficient SHBG increases MCR (your liver destroys T rapidly), allows for excessive metabolization to DHT and E2, and speeds up (per study!) the breakdown of testosterone in cells. Secondary pathways are starved. This is situation is either genetic, the result of excessive inflammation (or other disease state) or due to an excess of androgen in the body.

 

[eazy]

can’t do anything about it

walnuts, almonds, metformin, proviron, low body fat.

do not know mechanisms only that the number can be manipulated.

 

[Texan69]

How's your blood pressure?

Mood?

Are you experiencing skin problems?

How about your kidney and liver numbers?

I got some redness on my cheeks that has popped up two months ago

Kidney is fine
AST and ALT slightly elevated
Mood is fine
Blood pressure is good

 

[Gibsonator]

Not really. SHBG and Albumin are what transport testosterone (and estrogen) throughout the body. When Testosterone is bound to SHBG, it can't be used, but even though it has a high binding affinity, it's not permanent. It will release that Testosterone.

Albumin on the other hand, has a weaker binding affinity.

Funny I wouldn't have even known wtf ur talking about 3 years ago but I'm less than a year from my bachelors in human strength and performance

 

[Texan69]

View attachment 54653

of course he wouldn't worry he's not the guy with the 7, whose stuff is not getting where it needs to go

Is this actually true?

So taking a SERM…Nolvadex? Will raise it

In reality who knows …nobody lol…it seems like some compounds are gonna crash it and maybe this value isn’t important for a chemically enhance person But more so for a natural male who may have TT levels in range but suffering from low T symptoms

Will ask the doc when I see him and report back….if he even knows lol

 

[eazy]

Is this actually true?

technically yes. HOWEVER. the information is useless. the studies where this outcome was observed, do not apply to us.

for example they didn't study < LINK TO STUDY > if Toremifene (a serm) raised SHBG in men who drove it down using AAS, they studied it in men who suffer from idiopathic oligozoospermia (I'll let you google that )

 

[Texan69]

technically yes. HOWEVER. the information is useless. the studies where this outcome was observed, do not apply to us.

for example they didn't study < LINK TO STUDY > if Toremifene (a serm) raised SHBG in men who drove it down using AAS, they studied it in men who suffer from idiopathic oligozoospermia (I'll let you google that )

lol yes I googled that
Well judging that mine is a 7 and I made some gains and feel fine on bi weekly test E shots I think it’s prolly not a relevant value for us haha. Reddit says pin everyday to combat low SHGB …ya no thanks
Monday and Thursday work just fine

 

[Send0]

Is this actually true?

So taking a SERM…Nolvadex? Will raise it

In reality who knows …nobody lol…it seems like some compounds are gonna crash it and maybe this value isn’t important for a chemically enhance person But more so for a natural male who may have TT levels in range but suffering from low T symptoms

Will ask the doc when I see him and report back….if he even knows lol

The act of taking AAS tanks SHBG in most people. This is 10,000% normal and expected. It's also not something that can really be controlled very well as long as someone takes AAS. You can try everything in the world, and barely make a dent in raising it. As you said, this is not too important for a person on exogenous hormones. It's more relevant to nattys.

While SHBG does act as transport.for sex hormones, it's better to think of it like a speed governor on a car. It's really there to regulate the release of hormones available for use by the body in nattys specifically.

If this was really a problem, then no one would use steroids because they wouldn't work. The hormones you're taking still get to where they are going even with low SHBG. What changes is the rate at which you metabolize them. Again that's important for a natty since they produce base hormones (e.g. they do not have an ester attached). For people who use steroids, the ester acts as the regulator.

Ask your doctor about it, but don't kill yourself trying to do anything about it... It basically doesn't matter because the hormones we take have an ester attached.