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The main downside to taking HCG is that it has the potential to noticeably increase your e2I have found many articles over the years showing the taking HCG could have positive benefits. Probably why i have used it consistently for over 15 years. I can't see a downside to taking it so i will continue on with it. (It seems to do much more then make T or make for bigger balls.
Human chorionic gonadotropin induces neuronal differentiation of PC12 cells through activation of stably expressed lutropin/choriogonadotropin receptor - PubMed
Human chorionic gonadotropin (hCG) and LH play an important role in reproductive physiology. Both hCG and LH bind to the same LH/choriogonadotropin receptor (LH/CG-R). Recent reports documented the temporal and spatial expression of LH/CG-R in the developing and mature mammalian brain...pubmed.ncbi.nlm.nih.gov
Human Chorionic Gonadotropin Protects Vascular Endothelial Cells from Oxidative Stress by Apoptosis Inhibition, Cell Survival Signalling Activation and Mitochondrial Function Protection
Abstract. Background/Aim: Previous reports have made it hypothetically possible that human chorionic gonadotropin (hCG) could protect against the onset of pregnancy-related pathological conditions by acting as an antioxidant. In the present study we planned to examine the effects of hCG against...www.karger.com
But if you've been taking it for 15 years then it hasn't been an issue.