Pharmacom Labs officials and our Basicstero.ws

[thepcushion]

Price hikes are coming!

Dear Valued Customers!

We regret to inform you that, based on the latest market news and information, prices of raw materials have increased threefold.

This issue may persist for up to six months, and as a result, we must unfortunately announce that, in a week, we will have to raise the price of all items.

We would like to reassure our most loyalty customers that they can order at the current price for the time being!

 

[Jeffgoldblumlipswork]

Price hikes are coming!

Dear Valued Customers!

We regret to inform you that, based on the latest market news and information, prices of raw materials have increased threefold.

This issue may persist for up to six months, and as a result, we must unfortunately announce that, in a week, we will have to raise the price of all items.

We would like to reassure our most loyalty customers that they can order at the current price for the time being!

Seems like this happens every year

 

[thepcushion]

I agree man. I really really hated to type that crap again.

 

[thepcushion]

hey guys I have some important news pertaining to the future of our company and our ability to provide you with gear. I do no have to type everything up now. I will post later. Thank you for your patience and understanding.

 

[thepcushion]

Price hikes are coming!

Dear Valued Customers!

We regret to inform you that, based on the latest market news and information, prices of raw materials have increased threefold.

This issue may persist for up to six months, and as a result, we must unfortunately announce that, in a week, we will have to raise the price of all items.

We would like to reassure our most loyalty customers that they can order at the current price for the time being!

This news was already posted in multiple other threads and on the store website.
Nonetheless, I want to post it here as its own topic to help make sure all customers are informed.
I suspect the unfortunate situation is related to this (report on the government's website linked below):
"China-Based Chemical Manufacturing Companies and Employees Indicted...."

https://www.dea.gov/press-releases/2024/10/24/china-based-chemical-manufacturing-companies-and-employees-indicted

These are raw chemical companies, not finished product companies. Therefore, they make a variety of many types of raw chemicals. Some of the chemicals may be used to produce other types of products including drugs. They may get shut-down and arrested for one specific type of chemical; but if the factory is shut-down, none of the others chemicals are produced either.
Therefore, even though the government's main target may not be a chemical used to produce AAS, it still means we all lose access to raws when the chemical factories that produce the raws gets shut-down.

Guys, in my opinion if the products are important for you to have, I recommend you stock up now so you have some time to navigate the situation if/when the disruption in raws supply effects things.
This is genuine advice, not some marketing bullshit -- I just put in an order myself to make sure I'm good for my TRT for at least 6 months to a year.
Hopefully, everything will be ok and it won't matter, but it is better to make sure you have what you need now than being stressed in the future wishing you had prepared

For now this is all I know about it and it is not something any of us can control. I hope some new companies start up to fulfill the demand.
There is a lot of demand so there should still be motivation for other entrepreneurs to provide supply in the future.

I will be sure to share updates here or in the news threads if/when new information becomes available.
Thank you for your understanding.
Much love!!!!
Pcushion

 

[thepcushion]

Hello everyone.

Here is an update about the raw shortage situation.
By now, as has been recently announced, most of you already know about the raw situation in AAS industry (for more information, see the previous posts about it quoted below).
Sadly, all production of raws has been stopped; there is no new stock available at all, and if someone still has any remaining stock, the prices have already increased by 2-3 times higher.

Therefore, as expected, Pharmacom Labs is forced to increase prices as a result of these raw material shortages and the significant operational cost increases.
This means the prices in the Basicstero store have been increased.
Basicstero is trying to keep prices as low as possible and currently the store only has a slight increase in prices at this time. However, even higher prices are anticipated soon.

With the Holiday season and New Year coming, and soon afterwards the Chinese New Year, there is no additional news about the situation expected until March 2025.
By then everyone will be out of all stock. Sources will only be working with the stock they currently have and eventually everyone may be out of stock; if you search around, you can find that many brands already have nothing left to offer.

We are all hoping that things will be eventually be resolved and business will still be great, but for now we must work with the situation we have.

 

[thepcushion]

Hey guys, I hope everyone is ready for Christmas. I believe I have responded to everyone’s messages. I will be out of the office from 12/24-12-26. If I happened to miss anyone please reach back out to me.

 

[thepcushion]

On behalf of Pharmacom Labs I want to wish everyone a wonderful New Year. I wish for good fortune and prosperity for everyone.

 

[thepcushion]

PHARMATROPIN LIQUID – The New Liquid Growth Hormone Product from Pharmacom Labs! – is Now Available in the Basicstero Store.

The new growth hormone from Pharmacom Labs is a game-changer. We've been waiting for this for a long time. We all remember that for many years, the company has been providing the market with only a dry powder form of growth hormone, which has always caused a lot of inconvenience and questions regarding reconstitution, etc. After all, global brands like Omnitrope and Nordic have always produced growth hormone in liquid form.

Good news! Pharmacom's new growth hormone is now available in liquid form. The company's experts have revised the formulation, making it one of the most advanced on the market. Now it's been purified, and the molecular structure is stable, so it can be stored outside the refrigerator for up to 30 days in a cool, dark place. Previously, the storage period for liquid growth hormone was only three days, which made logistics a lot more complicated.

The new package is a 5 ml vial of liquid. Each milliliter of the product contains 10 international units (IU) of growth hormone, which is already prepared for injection. All you have to do is draw it into an insulin syringe and inject it.

You can easily see how much product you've taken into the syringe. One unit on a standard insulin syringe is equal to one unit of this growth hormone. So, if you use three units of the hormone per day, you'll need to inject three units from the syringe volume.

This new Growth Hormone product is currently offered as two 5 mL vials containing 50 iu each of Liquid GH (for a total of 100 iu) at:

 basicstero.ws/hgh-and-peptides/pharmatropin-liquid

 

[thepcushion]

Dear customers,

We wanted to let you know that the Spring Festival, also known as Chinese New Year, is coming up soon. It's from January 23rd to February 6th this year. Just a heads-up, delivery services won't be available during this time.

For that reason, we're going to ship today's orders from Int. Warehouse for the last time before the holidays! We'll keep taking orders during the Spring Festival, but they won't ship out until around February 6th.

Please keep in mind that Chinese New Year might slow down the processing of orders from International Warehouse.

Thanks,
Pharmacomlabs team.

 

[thepcushion]

Good morning everyone. I hope everyone is preparing for a wonderful weekend. We have some awesome things in the works, so stay tuned. I believe I responded to everyone’s messages. If I missed someone please forgive me and shoot me another message so I can handle anything you may handled. I hope everyone has a great weekend.

 

[thepcushion]

The new GH product has been restocked in the "local" warehouse:

 https://basicstero.ws/hgh-and-peptides/pharmatropin-liquid

 

[thepcushion]

The International Warehouse has returned to work and shipping orders again now that this year's Spring Festival / Chinese New Year holiday has concluded.

 

[thepcushion]

Another fresh restock!

 https://basicstero.ws/hgh-and-peptides/pharmatropin-liquid

 

[thepcushion]

Pharma TEST-U250 – Testosterone Undecanoate, The Optimal Product for Convenient TRT! – is Available in the Basicstero Store.

Testosterone Undecanoate in a 250 mg/mL preparation from Pharmacom Labs is available at: basicstero.ws/testosterones/pharmatest-u-250

Testosterone undecanoate is the optimal product for hormone replacement therapy in men.

Research has demonstrated that testosterone levels in men over 40 years of age naturally decline, impacting both physical and mental well-being. This decline can cause a decrease in muscle mass, an increase in fat deposits, and a decline in libido and potency. Additionally, there may be an emotional decline, often coinciding with the concept of the "midlife crisis." Overall quality of life can be negatively impacted by low testosterone.

However, this decline can be mitigated by testosterone replacement therapy (TRT), which involves the administration of small doses of testosterone undecanoate, a long-acting testosterone ester, on a monthly basis. This treatment has been shown to enhance libido, improve energy levels, and enhance overall quality of life. Energy and activity are vital for maintaining good health and wellness. The unique super-long ester, undecanoate, minimizes the frequency of injections required, and the convenient application pattern ensures a stable hormonal background.

Pharmacom Labs Pharma TEST-U250 is the superior choice for TRT.
If it’s for TRT, the best choice is testosterone-U; If it’s testosterone-U, the best choice is Pharmacom Labs.

Testosterone-Undecanoate Information (credit: Llewellyn, William. “ANABOLICS” 11th ed. 2017.):
Testosterone undecanoate (primarily marketed and known from the trade-name “Nebido”), is a very slow-acting ester of testosterone. This is the active drug that is used in Andriol, but in that case it is part of an oral medication, not an injectable. Nebido is being marketed as a replacement for established injectable testosterone products like Delatestryl®, DepoTestosterone®, and Sustanon®, which are actually much faster acting in comparison. It is designed to offer a much less frequent injection schedule, and, therefore, much greater comfort for the patient. Nebido is a drug developed under a similar focus as testosterone buciclate, which is another very slow-acting injectable ester of testosterone.

History (credit: Llewellyn, William. “ANABOLICS” 11th ed. 2017.):
Nebido® was developed by international giant Schering AG, Germany (now Bayer). It first surfaced as a prescription drug in Finland and Germany in October and November of 2004, respectively. Within a year it had been approved for sale throughout Europe. Schering/Bayer has since also brought this product to Mexico, Brazil, Argentina, South Africa, Colombia, Korea, Venezuela, and various countries in Eastern Europe (86 countries in total). In July 2005, the U.S. pharmaceuticals firm lndevus purchased the rights to market Nebido under the Aveed trade name. The FDA has since held up U.S. approval of the drug, however, focusing on a small number of adverse reports in Germany. These specifically involve post-injection anaphylactic reactions and pulmonary oil microembolism. Most of these reactions are likely not due to a problem with the drug itself, but incorrect administration of the high-volume injection. Future approval in the U.S. is expected, but unclear.

Nebido® was described by Schering as being the, "first long-acting injection for the treatment of male hypogonadism." This may be a matter of perspective, as other slow-acting esters do exist. Schering, however, is taking the lead to market in most regions. The applications for Nebido® are extremely narrow, being approved for use in men as a long-term treatment option for low androgen levels only. It is not labeled for use in women, or in males for other uses. Given the growing acceptance of androgen replacement therapy, and the comfort advantage that Nebido® seems to offer male hormone replacement therapy patients (esters like enanthate and cypionate generally require between 13 and 26 injections per year), it may very well become a dominant testosterone product in the years to come, especially with the marketing support of a pharmaceutical giant like Bayer.

Structural Characteristics (credit: Llewellyn, William. “ANABOLICS” 11th ed. 2017.):
Testosterone undecanoate is a modified form of testosterone, where a carboxylic acid ester (undecanoic acid) has been attached to the 17-beta hydroxyl group. Esterified forms of testosterone are less polar than free testosterone, and are absorbed more slowly from the area of injection. Once in the bloodstream, the ester is removed to yield free (active) testosterone. Esterified forms of testosterone are designed to prolong the window of therapeutic effect following administration, allowing for a less frequent injection schedule compared to injections of free (unesterified) steroid. Nebido® is designed to maintain physiological levels of testosterone for up to 14 weeks after injection.

Side Effects (Estrogenic) (credit: Llewellyn, William. “ANABOLICS” 11th ed. 2017.):
Testosterone is readily aromatized in the body to estradiol (estrogen). The aromatase (estrogen synthetase) enzyme is responsible for this metabolism of testosterone. Elevated estrogen levels can cause side effects such as increased water retention, body fat gain, and gynecomastia. Testosterone is considered a moderately estrogenic steroid. An anti-estrogen such as clomiphene citrate or tamoxifen citrate may be necessary to prevent estrogenic side effects. One may alternately use an aromatase inhibitor like Arimidex® (anastrozole), which more efficiently controls estrogen by preventing its synthesis. Aromatase inhibitors can be quite expensive in comparison to anti-estrogens, however, and may also have negative effects on blood lipids.

Estrogenic side effects will occur in a dose-dependent manner, with higher doses (above normal therapeutic levels) of testosterone more likely to require the concurrent use of an anti-estrogen or aromatase inhibitor. Since water retention and loss of muscle definition are common with higher doses of testosterone, this drug is usually considered a poor choice for dieting or cutting phases of training. Its moderate estrogenicity makes it more ideal for bulking phases, where the added water retention will support raw strength and muscle size, and help foster a stronger anabolic environment.

Side Effects (Androgenic) (credit: Llewellyn, William. “ANABOLICS” 11th ed. 2017.):
Testosterone is the primary male androgen, responsible for maintaining secondary male sexual characteristics. Elevated levels of testosterone are likely to produce androgenic side effects including oily skin, acne, and body/facial hair growth. Men with a genetic predisposition for hair loss (androgenetic alopecia) may notice accelerated male pattern balding.Those concerned about hair loss may find a more comfortable option in nandrolone decanoate, which is a comparably less androgenic steroid. Women are warned of the potential virilizing effects of anabolic/androgenic steroids, especially with a strong androgen such as testosterone. These may include deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth,and clitoral enlargement.

In androgen-responsive target tissues such as the skin, scalp, and prostate, the high relative androgenicity of testosterone is dependent on its reduction to dihydrotestosterone (DHT). The 5-alpha reductase enzyme is responsible for this metabolism of testosterone. The concurrent use of a 5-alpha reductase inhibitor such as finasteride or dutasteride will interfere with site-specific potentiation of testosterone action, lowering the tendency of testosterone drugs to produce androgenic side effects. It is important to remember that anabolic and androgenic effects are both mediated via the cytosolic androgen receptor. Complete separation of testosterone's anabolic and androgenic properties is not possible, even with total 5-alpha reductase inhibition.

Side Effects (Hepatotoxicity) (credit: Llewellyn, William. “ANABOLICS” 11th ed. 2017.):
Testosterone does not have hepatotoxic effects; liver toxicity is unlikely. One study examined the potential for hepatotoxicity with lnigh doses of testosterone by administering 400 mg of the hormone per day (2,800 mg per week) to a group of male subjects. The steroid was taken orally so that higher peak concentrations would be reached in hepatic tissues compared to intramuscular injections. The hormone was given daily for 20 days, and produced no significant changes in liver enzyme values including serum albumin, bilirubin, alanine-aminotransferase, and alkaline phosphatases.

Side Effects (Cardiovascular) (credit: Llewellyn, William. “ANABOLICS” 11th ed. 2017.):
Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable), type of steroid (aromaitizable or non-aromatizable), and level of resistance to hepatic metabolism. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction.

Testosterone tends to have a much less dramatic impact on cardiovascular risk factors than synthetic steroids. This is due in part to its openness to metabolism by the liver, which allows it to have less effect on the hepatic management of cholesterol. The aromatization of testosterone to estradiol also helps to mitigate the negative effects of androgens on serum lipids. In one study, 280 mg per week of testosterone ester (enanthate) had a slight but not statistically significant effect on HDL cholesterol after 12 weeks, but when taken with an aromatase inhibitor a strong (25%) decrease was seen. Studies using 300 mg of testosterone ester (enanthate) per week for twenty weeks without an aromatase inhibitor demonstrated only a 13% decrease in HDL cholesterol, while at 600 mg the reduction reached 21%. The negative impact of aromatase inhibition should be taken into consideration before such drug is added to testosterone therapy.

Due to the positive influence of estrogen on serum lipids, tamoxifen citrate or clomiphene citrate are preferred to aromatase inhibitors for those concerned with cardiovascular health, as they offer a partial estrogenic effect in the liver. This allows them to potentially improve lipid profiles and offset some of the negative effects of androgens. With doses of 600 mg or less per week, the impact on lipid profile tends to be noticeable but not dramatic, making an anti-estrogen (for cardioprotective purposes) perhaps unnecessary. Doses of 600 mg or less per week have also fai led to produce statistically significant changes in LDLNLDL cholesterol, triglycerides, apolipoprotein B/C-111, (-reactive protein, and insulin sensitivity, all indicating a relatively weak impact on cardiovascular risk factors. When used in moderate doses, injectable testosterone esters are usually considered to be the safest of all anabolic/androgenic steroids.

To help reduce cardiovascular strain it is advised to maintain an active cardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates at all times during active AAS administration. Supplementing with fish oils (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a product with comparable ingredients is also recommended.

Administration (General) (credit: Llewellyn, William. “ANABOLICS” 11th ed. 2017.):
Due to the large injection volume, prescribing guidelines recommend that each injection be given slowly, taking approximately 60 seconds to administer the full 4ml dose. Nebido® should always be injected deep in the gluteal muscle.

Availability (credit: Llewellyn, William. “ANABOLICS” 11th ed. 2017.):
Testosterone undecanoate injection continues to increase in prominence as a pharmaceutical product. It is presently approved for sale in more than 80 countries worldwide. In reviewing some of the more popular products and changes on the global pharmaceutical market, we have made the following observations.
Nebido gained approval for Europe-wide sales in 2005. The product is has since distributed throughout Europe, and is widely available in this region.
lndevus, a subsidiary of Endo Pharmaceuticals, received U.S. FDA approval in 2014 for the sale of Aveed.