New drug to lower hematocrit and thick blood

j2048b · Apr 4, 2024

https://www.nejm.org/doi/full/10.1056/NEJMoa2308809

Anyone ever used rustfertide???

Megatron28 · Apr 4, 2024

interesting! I’m sure many of us here will be keeping a watchful on this drug. From what I could gather, they are going to seek FDA approval in late 2025 so it will probably be quite a while before it’s on the market. I also saw that they recently entered into a contract with Takeda to manufacture and market the drug globally.

j2048b · Apr 4, 2024

Megatron28 said:
interesting! I’m sure many of us here will be keeping a watchful on this drug. From what I could gather, they are going to seek FDA approval in late 2025 so it will probably be quite a while before it’s on the market. I also saw that they recently entered into a contract with Takeda to manufacture and market the drug globally.

Yup very interesting to say the least… hopefully not any weird side effects but who knows

andy · Apr 4, 2024

somebody correct me if im wrong , but does that mean u have thicker blood ?
if thats the case - take a supplement named nattokinase , hands down best

snake · Apr 4, 2024

andy said:
somebody correct me if im wrong , but does that mean u have thicker blood ?
if thats the case - take a supplement named nattokinase , hands down best

That's the concern. Your blood is too thick moving through the pipes. I had this conversation with my Cardio about 6 months ago during some routine testing. The concern is blood clots. My crits are always 50 ±. He said he's not concerned because I'm active, BW and Sed Rate is always good plus I do a Baby Aspirin each night.

andy · Apr 4, 2024

snake said:
That's the concern. Your blood is too thick moving through the pipes. I had this conversation with my Cardio about 6 months ago during some routine testing. The concern is blood clots. My crits are always 50 ±. He said he's not concerned because I'm active, BW and Sed Rate is always good plus I do a Baby Aspirin each night.

it kinda would make sense if your active (especially with weights) your blood should have a good flow as it's constantly moving around during your workouts. im always feeling much better after my workouts and I just can feel the bloodflow all around my body is good

oilfeildtrash · Apr 5, 2024

Megatron28 said:
interesting! I’m sure many of us here will be keeping a watchful on this drug. From what I could gather, they are going to seek FDA approval in late 2025 so it will probably be quite a while before it’s on the market. I also saw that they recently entered into a contract with Takeda to manufacture and market the drug globally.

Who makes this drug

Henry B · Apr 5, 2024

Nattokinase and stay hydrated, I mean really hydrated. Keep drinking until you urinate clear by noon and keep going, slowing down in the evening. This works as I was THAT GUY.

andy · Apr 6, 2024

Henry B said:
Nattokinase and stay hydrated, I mean really hydrated. Keep drinking until you urinate clear by noon and keep going, slowing down in the evening. This works as I was THAT GUY.

in theory u actually can drink TOO much water and damage inner organs like liver - but the person would really had to try hard to do it.
for my body I would drink aprox 6-7L a day but my urine would be yellow because of all the vitamins and minerals i'd take so that's not pointer unleass u dont take vitamins at all - then your piss would be crystal clear

j2048b · Apr 6, 2024

andy said:
somebody correct me if im wrong , but does that mean u have thicker blood ?
if thats the case - take a supplement named nattokinase , hands down best

I cant it makes me get nose bleeds…

Henry B · Apr 6, 2024

andy said:
in theory u actually can drink TOO much water and damage inner organs like liver - but the person would really had to try hard to do it.
for my body I would drink aprox 6-7L a day but my urine would be yellow because of all the vitamins and minerals i'd take so that's not pointer unleass u dont take vitamins at all - then your piss would be crystal clear

I use Animal Pack products and take in the a.m and I back off in the evening. The That Guy comment was one morning I was struggling with balance, equilibrium and speech and before you know it I was in an ambulance on stoke protocol. A could of days later, $30,000 spent, it was chalked up to dehydration. Sooooo.....I'm motivated. Hope this helps you in some way.

j2048b · Apr 7, 2024

oilfeildtrash said:
Who makes this drug

I think it says in the article? Its new and almost g2g…. Hell ill jump on it thru my doc asap if so… then juice my brains out haha jk…

almostgone · Apr 7, 2024

Takeda has entered a global licence and partnership agreement with Protagonist Therapeutics to develop and market rusfertide.

Takeda and Protagonist sign rusfertide development deal

Takeda has entered a global licence and partnership agreement with Protagonist Therapeutics for developing and marketing rusfertide.

www.pharmaceutical-technology.com

Yano · Apr 7, 2024

There is no cure for Polycethemia it can only be managed as far as I know when we don't cause it ourselves with gear and even then you can end up fucked.

Most Docs will give you Hydroxyurea for it , that's the most common. If you start having issues with that sometimes they will go with Ruxolitinib but that's more for people moving into the next stage of PV which is myelofibrosis , that or it's given to folks that cant tolerate or take the Hydrox.

If you have issues with either of those and have to be given an alternate they start talking to you about Interferon.

Pudding blood is no joke.

almostgone · Apr 7, 2024

Yano said:
There is no cure for Polycethemia it can only be managed as far as I know when we don't cause it ourselves with gear and even then you can end up fucked.

Most Docs will give you Hydroxyurea for it , that's the most common. If you start having issues with that sometimes they will go with Ruxolitinib but that's more for people moving into the next stage of PV which is myelofibrosis , that or it's given to folks that cant tolerate or take the Hydrox.

If you have issues with either of those and have to be given an alternate they start talking to you about Interferon.

Pudding blood is no joke.

It's a real b!tch of a balancing act, that's for sure.

Big-paul · Apr 8, 2024

Megatron28 said:
interesting! I’m sure many of us here will be keeping a watchful on this drug. From what I could gather, they are going to seek FDA approval in late 2025 so it will probably be quite a while before it’s on the market. I also saw that they recently entered into a contract with Takeda to manufacture and market the drug globally.

I wonder what sides go with it? It beats a stroke though. I have had serious problems with hct. I've had to make some changes to keep it down. No more cycles or daily dope smoking. It got so bad I had to do a 400ml blood drop every week.

New drug to lower hematocrit and thick blood

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